YEARS Core® was designed from the ground up as a clinical translation of epidemiology. Drawing on evidence from some of the world’s largest population studies, we reverse-engineered which diagnostics and biomarkers most reliably predict age-related disease. The result is a targeted panel of 25+ functional examinations and 80+ biomarkers that capture the earliest, silent deviations in organ, metabolic, and vascular health. This framework delivers a scientifically rigorous baseline—enabling precise, personalized strategies to slow age-related decline and extend healthspan.
 

The YEARS Ultimate® Panel is our most advanced and comprehensive diagnostic panel, analyzing more than 200 biomarkers across all major physiological systems. Building on the Evolve® Panel, it expands into autoimmune markers, infection screening (HBV, HCV, HIV), cytokine profiling, microbiome analysis, oxidative stress markers (e.g., TMAO, CoQ10), immunoglobulin subclasses, amino acids, nicotinamide, Vitamin B1, and other experimental longevity markers. This breadth captures subtle patterns across cardiovascular, metabolic, immune, inflammatory, and molecular domains—providing a research-grade foundation for precision prevention, risk stratification, and advanced longevity assessment.

Understanding genetic risk factors enables informed decisions and targeted prevention. Awareness can support earlier detection and timely intervention. Medical Genomics within the Ultimate® Program analyzes more than 170 risk genes for cancer, cardiovascular, and metabolic disorders, alongside pharmacogenomics for ~150 medications. Using Whole Exome Sequencing, complemented by Whole Genome Sequencing, it delivers clinically validated guidance for medical decisions—unlike lifestyle genetic tests, which often lack regulatory oversight and strong evidence.

This liquid biopsy test rules out cancer using a simple blood sample, identifying apoptosis-resistant circulating tumor-associated cells (C-ETACs) with high specificity (96%-99%) and sensitivity (65%-89%), with sensitivity increasing as tumors progress. Designed for individuals aged 40-70 (or 35+ with a family history of cancer), it enables proactive screening before symptoms appear. Our liquid biopsy supports remission monitoring, benign condition evaluation, and routine cancer surveillance. Using advanced cell-enrichment technology, it ensures precise detection of malignancies. 

The Whole-Body MRI is an advanced modality for preventive health monitoring, using a proprietary YEARS sequence across neurological, vascular, and oncological domains. It identifies subclinical structural changes relevant to disorders such as multiple sclerosis, brain tumors, aneurysms, fatty liver, intra-abdominal fat, and vascular abnormalities—key markers of metabolic dysfunction. This multi-organ scan also evaluates lung, liver, and spinal health, providing a comprehensive overview of potential oncological and systemic risks.

As part of the Ultimate® Program, blood, stool, urine, and saliva are processed into 70 cryopreserved samples, including immune cells (PBMCs), plasma, serum, red blood cells, and genetic material such as ccfDNA, mRNA, and microbiome DNA. These samples capture a biological snapshot at collection, creating a resource for future testing. Cryopreserving viable cells, especially PBMCs, provides a form of immune “backup” that may support future applications in immunotherapy, regenerative medicine, and biotechnology—depending on scientific progress. Banking biomaterials today secures optionality for tomorrow’s medical innovations.

Epigenetic clocks are experimental tools that analyze DNA methylation patterns to estimate biological aging and health risk. Early models (Horvath, Hannum) correlated methylation with chronological age, while newer clocks (PhenoAge, GrimAge, DunedinPACE) integrate inflammatory and lifestyle factors for greater accuracy. These measures provide insight into aging dynamics and can inform preventive strategies, as accelerated epigenetic age is linked to higher risk of age-related disease.
 

The YEARS Performance Battery provides a precise diagnostic profile of fitness, mobility, and strength. Using 3D body scanning, VALD movement and force diagnostics, and ergospirometry, it identifies asymmetries, weaknesses, and metabolic limits. These findings directly translate into targeted exercise, nutrition, and recovery strategies—helping optimize performance, prevent injury, and extend physical resilience. For example, detecting declining strength or impaired balance enables early interventions to prevent frailty and reduce future fall risk.

Your health is supported year-round through structured monitoring and physician-guided care. Depending on your goals, tools such as CGM, sleep tracking, or blood pressure monitoring are applied. Regular check-ins—remote and in-person—ensure precise adjustments, while monthly coaching in fitness, nutrition, and sleep refines your strategy. This curated approach keeps your prevention plan personalized, adaptive, and always ahead.

Our on-demand Healthspan Concierge provides 10 hours of expert guidance on prevention, advanced diagnostics, and emerging therapies. We deliver evidence-based recommendations, critical analysis of novel interventions, and precise data interpretation. For specific health concerns, Dr. Alex Ardelean offers tailored medical insights to guide proactive management, optimize interventions, and support resilience and long-term performance.